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KMID : 1149220080160010079
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Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 1 p.79 ~ p.94
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Anti-Inflammatory Effects of Ji-Pae-San Water Extract
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Lee Sang-Hyun
Park Chan-Ki
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Abstract
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Although inflammatory mediators such as nitric oxide(NO) and pro-inflammatory cytokines are involved in host defense mechanism, these overproduction contributes to the pathogenesis of several diseases such as otitis media, hearing loss, periodontitis, bacterial sepsis, rheumatoid arthritis, chronic inflammation and autoimmune diseases. We investigate the anti-inflammatory effects of water extract from Ji-Pae-San(JPSWE) fomulated with Angelica dahurica plus Fritillaria Verticillata, Angelica dahurica(ADWE), and Fritillaria Verticillata(FUVE) in vitro and in vivo. Each extract inhibited the production of inflammatory mediators(NO,1L-1β, IL-6, TNF-α ,and prostaglandin E2)and the expression of inducible NO synthase(iNOS) and cyclooxygenase-2(COX-2) in lipopolysaccharide(LPS)-stimulated RAW 264.7 macrophages in a dose-dependent manner. These inhibitory effects were synergistically increased by their combination. JPSWE also inhibited TNF-α, 1L-1β, IL-6. and PGE2 production as well as COX activity in LPS-stimulated mice. Moreover, JPSWE significantly suppressed death by LPS-septic shock in mice(survival rate: 100%). These results suggest that Ji-Pae-San may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
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KEYWORD
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Ji-Pae-San, Angelica dahurica, Fritillaria Verticillata inflammatory mediators
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